The most pregnancy friendly lubricants are the water based kinds. These lubes are water soluble, which means they dissolve in water. They're safer for you and your baby, typically because they contain fewer chemicals than Is it safe to use a Lubricant when trying for pregnancy? Dr. Anjali Kumar Maitri Is Lube Safe: By Type, Sexual Activity, & Ingredients To Avoid Is Lube Safe During Pregnancy? Your Guide [OBGYN Provided] Quanna Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your